GENETICS OF DEMENTIA: THE CANDIDATE GENES AND AVAILABLE GENETIC TESTINGS

Ziske Maritska* -  Universitas Sriwijaya, Indonesia
Diah Andini -  Universitas Sriwijaya, Indonesia
Febryana Ramadhani Machyar -  Universitas Sriwijaya, Indonesia
Rachmat Taufan -  Universitas Sriwijaya, Indonesia
Try Merdeka Puri -  Universitas Sriwijaya, Indonesia
Tryvanie R Putra -  Universitas Sriwijaya, Indonesia
Uswati Uswati -  Universitas Sriwijaya, Indonesia
Bintang Arroyantri Prananjaya -  Universitas Sriwijaya, Indonesia
Rini Nindela -  Universitas Sriwijaya, Indonesia
Nita Parisa -  Universitas Sriwijaya, Indonesia

DOI : 10.24269/ijhs.v7i2.6353

When dementia is present, a person's memory, reasoning, behavior, and even their capacity to carry out day-to-day chores can all become distorted. This syndrome remains present and actually worsens as time passes. It's possible that synapse loss, death and dysfunction of brain cells, gliosis, and inflammation are all factors in the progression of dementia. The clinical syndrome, age, and a history of the ailment in the patient's family should dictate the choices made about counseling and testing. Dementia is known as a multifactorial condition, brought on by the combination of strong genetic factors and environmental factors. There are several candidate genes  associated with Dementia; APP, PSEN1, and PSEN2 genes, in addition to the GRN and MAPT genes. This literatura review provide insight on the genetic of Dementia, particularly in the genetic causes and testings

Keywords
Dementia, Genetic, Genetic factors
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Submitted: 2022-12-17
Published: 2023-09-20
Section: Artikel
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