EFFECT OF ASHITABA (Angelica keiskei) IN LOWERING BLOOD GLUCOSE LEVELS IN MICE (Mus musculus L.)

Authors

  • Musparlin Halid Politeknik Medica Farma Husada Mataram, Indonesia
  • Sri Rahmawati Politeknik Medica Farma Husada Mataram, Indonesia

DOI:

https://doi.org/10.24269/ijhs.v7i2.6588

Abstract

Ashitaba has been traditionally used for its potential health benefits and is generally considered safe when consumed as part of a balanced diet, it's essential to approach its usage with caution and consult a healthcare professional before starting any new supplement regimen. The study was conducted to determine the activity of ashitaba leaf extract (Angelica keiskei) on reducing blood glucose levels in alloxan-induced mice. This research method is pre and post-control group design. Twenty-five mice were divided into five treatment groups. Group I (negative control) was given PEG 4000, group II (positive control) was given glibenclamide, and groups III, IV, and V were given Ashitaba leaf extract at 300, 600, and 1200 mg/kg BW doses. The study results were divided into 2 groups, namely groups of mice with Pre-Diabetes Mellitus and groups of mice with Diabetes Mellitus. The 1200 mg/kg BW dose of Ashitaba (Angelica keiskei) leaf extract has the highest activity in reducing blood glucose levels in the group of mice with Pre-Diabetes Mellitus, while the 600 mg/kg BW dose of Ashitaba (Angelica keiskei) leaf extract has the highest activity in reducing blood glucose levels in mice with Diabetes Mellitus. Thus, Ashitaba leaf extract can reduce blood glucose in mice

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References

[1] R. I. Putri, “Determinants of diabetic nephropathy in patients with diabetes mellitus at RSUD DR. M. Soewandhie Surabaya,” J. Berk. Epidemiol., vol. 3, pp. 109–121, 2015, [Online]. Available: https://media.neliti.com/media/publications/76507-ID-none.pdf
[2] N. N. Veridiana and M. A. Nurjana, “Hubungan Perilaku Konsumsi dan Aktivitas Fisik dengan Diabetes Mellitus di Indonesia (The Correlation Consumption Behavior and Physical Activity with Diabetes Mellitus in Indonesia),” Bul. Penelit. Kesehat., vol. 47, no. 2, pp. 97–106, 2019.
[3] P. S. Nugroho and A. C. Wijayanti, “Body Mass Index and Its Relation to Diabetes Mellitus at the Age of > 15 Years in Indonesia, Study of Indonesian Family Life Survey Data V,” J. Publ. Kesehat. Masy. Indones., vol. 5, no. 1, p. 12, 2018, doi: 10.20527/jpkmi.v5i1.4998.
[4] M. J. Lede, T. Hariyanto, and V. M. Ardiyani, “The Effect of Blood Sugar Levels on Diabetes Mellitus Wound Healing at Dinoyo Health Center Malang,” Nurs. News (Meriden)., vol. 3, no. 1, p. 547, 2018.
[5] N. Ohkura, G. Atsumi, K. Ohnishi, K. Baba, and M. Taniguchi, “Possible antithrombotic effects of Angelica keiskei (Ashitaba),” Pharmazie, vol. 73, no. 6, pp. 315–317, 2018, doi: 10.1691/ph.2018.8370.
[6] M. Kweon, H. Lee, C. Park, Y. H. Choi, and J. H. Ryu, “A chalcone from ashitaba (Angelica keiskei) stimulates myoblast differentiation and inhibits dexamethasone-induced muscle atrophy,” Nutrients, vol. 11, no. 10, pp. 1–13, 2019, doi: 10.3390/nu11102419.
[7] D. L. Aulifa, I. K. Adnyana, J. Levita, and S. Sukrasno, “4-Hydroxyderricin isolated from the sap of Angelica keiskei koidzumi: Evaluation of its inhibitory activity towards dipeptidyl peptidase-iv,” Sci. Pharm., vol. 87, no. 4, pp. 3–12, 2019, doi: 10.3390/scipharm87040030.
[8] M. Ohta, A. Fujinami, K. Oishi, N. Kobayashi, K. Ohnishi, and N. Ohkura, “Ashitaba (Angelica keiskei) Exudate Prevents Increases in Plasminogen Activator Inhibitor-1 Induced by Obesity in Tsumura Suzuki Obese Diabetic Mice,” J. Diet. Suppl., vol. 16, no. 3, pp. 331–344, May 2018, doi: 10.1080/19390211.2018.1458366.
[9] A. K. Wardani, S. Malfadinata, and Y. Fitriana, “Test of Antibacterial Activity of Acne Causes of Staphylococcus epidermidis Using Ashitaba Leaf Extract (Angelica keiskei).,” Lumbung Farm. J. Ilmu Kefarmasian, vol. 1, no. 1, p. 14, 2020, doi: 10.31764/lf.v1i1.1206.
[10] L. K. Caesar and N. B. Cech, “A review of the medicinal uses and pharmacology of ashitaba,” Planta Med., vol. 82, no. 14, pp. 1236–1245, 2016, doi: 10.1055/s-0042-110496.
[11] I. P. A. Wiralaga, I. W. Sudira, I. M. Kardena, and A. A. G. O. Dharmayudha, “The effect of ethanol extract of ashitaba leaves on the histopathology of the stomach of male mice,” Bul. Vet. Udayana, vol. 7, no. 1, pp. 26–33, 2015,
[12] H. T. C. Fuentebella et al., “Comparative study: Banana-polyester fiber with guava extract (GuaBaNIKA sock) as an alternative to cotton in prosthetic socks,” UERM Heal. Sci. J., vol. 8, no. 2, pp. 108–114, 2019.
[13] N. Ohkura et al., “Anti-platelet effects of chalcones from Angelica keiskei Koidzumi (Ashitaba) in vivo,” Pharmazie, vol. 71, no. 11, pp. 651–654, 2016, doi: 10.1691/ph.2016.6678.
[14] N. Ohkura, G. Atsumi, S. Uehara, M. Ohta, and M. Taniguchi, “Ashitaba (Angelica keiskei) Exerts Possible Beneficial Effects on Metabolic Syndrome,” OBM Integr. Complement. Med., vol. 4, no. 1, pp. 1–1, 2018, doi: 10.21926/obm.icm.1901005.
[15] L. Zhang et al., “Simultaneous Optimization of Ultrasound-Assisted Extraction for Flavonoids and Antioxidant Activity of Angelica keiskei Using Response Surface Methodology (RSM),” Molecules, vol. 24, no. 19, 2019, doi: 10.3390/molecules24193461.
[16] T. Zhang et al., “The Ashitaba (Angelica keiskei) Chalcones 4-hydroxyderricin and xanthoangelol suppress melanomagenesis by targeting BRAF and PI3K,” Cancer Prev. Res., vol. 11, no. 10, pp. 607–619, 2018, doi: 10.1158/1940-6207.CAPR-18-0092.
[17] K. Iimura, J. I. Hattan, N. Misawa, and K. Shindo, “CDNA cloning and functional analyses of ashitaba (Angelica keiskei) sesquiterpene synthase genes,” J. Oleo Sci., vol. 69, no. 7, pp. 711–718, 2020, doi: 10.5650/jos.ess19275.
[18] A. A. Devanadera, C. G. M. Peña, and J. L. R. Perez, “Anti-hyperglycemic and Anti-hypercholesterolemic Effects of,” Lyceum Philipp. Cabrini Coll. Allied Med. Res., vol. 2, no. 2, pp. 29–38, 2017.
[19] J. A. M. Tattao, R. R. Velasco, and J. S. Doctolero, “Potential of ashitaba ( Angelica keiskei Koidzumi ) leaves as a feed additive on the diet of Nile tilapia fry ( Oreochromis niloticus L . ),” Int. J. Fish. Aquat. Stud., vol. 8, no. 1, pp. 16–19, 2020.
[20] Y. S. Kil, S. T. Pham, E. K. Seo, and M. Jafari, “Angelica keiskei, an emerging medicinal herb with various bioactive constituents and biological activities,” Arch. Pharm. Res., vol. 40, no. 6, pp. 655–675, 2017, doi: 10.1007/s12272-017-0892-3.
[21] S. Rahmi and A. Kartini, “The Effect of Extract ( Angelica keiskei ) on Reducing Blood Pressure Level among Post-Partum Period with Hypertension,” Int. J. Nurs. Heal. Serv., vol. 3, no. 1, pp. 192–199, 2020, doi: 10.35654/ijnhs.v3i1.272.

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Published

2023-09-20

Issue

Vol. 7 No. 2 (2023): September

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