EFFECTIVENESS OF ANTIBACTERIAL EXTRACT OF KENOP (GOMPHRENA GLOBOSA) FLOWER EXTRACT AGAINST GROWTH OF PROPIONIBACTERIUM ACNES BACTERIA
DOI:
https://doi.org/10.24269/ijhs.v4i2.2620Abstract
Acne is a chronic inflammation of the pilosebaceous tissue caused by the bacterium Propionibacterium acne (P.acnes) which often experiences antibiotic resistance. Research on the benefits of herbal plants in dealing with acne is still needed, one of which is the use of Knobs flowers (Gomphrena globosa) which is easily found and has potential as an antioxidant and antibacterial. This study aims to determine the effectiveness of the extract of the flower knob in inhibiting the growth of P.acnes bacteria. The design of this study was purely experimental with the Kirby-Bauer method using MHA (Mueller Hinton Agar) media. A positive control using clindamycin antibiotics and negative control using aquadest. The treatment group consisted of 25%, 50%, 75%, and 100% knob methanol extract with 3 replications. Data analysis using One Way ANOVA to find out the average difference between treatment groups. Based on the results of the study, it was found that the higher the concentration of the extract, the greater the inhibitory power as long as the extract had not reached saturated concentration (p <0.05). There is a decrease in the inhibition zone diameter at 100% concentration because it is influenced by the diffusion rate of a compound and other factors.
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References
[2] A. L. Zaenglein, “Acne vulgaris,†N.  Engl. J. Med., vol. 379, no. 14, pp.  1343–1352, 2018, doi:  10.1056/NEJMcp1702493.
[3] N. H. Cox, Fitzpatrick’s  Dermatology in General Medicine.,  7th ed., vol. 150, no. 4. New York:  McGraw-Hill, 2012.
[4] S. Arumugam and K. Watanabe,  Japanese Kampo Medicines for the  Treatment of Common Diseases:  Focus on Inflammation. Niigata:  Elsevier, 2017.
[5] K. Bhate and H. C. Williams,  “Epidemiology of acne vulgaris,†Br.  J. Dermatol., vol. 168, no. 3, pp.  474–485, 2013, doi:  10.1111/bjd.12149.
[6] M. E. Portillo, S. Corvec, O. Borens,  and A. Trampuz, “Propionibacterium  acnes: An underestimated pathogen  in implant-associated infections,† Biomed Res. Int., vol. 2013, 2013,  doi: 10.1155/2013/804391.
[7] A. B. S. Satyarsa, “Potential Effects  of Alkaloid vindolicine Substances in  Tapak Dara Leafs (Catharanthus  roseus (L.) G. Don) in Reducing  Blood Glucose Levels,†J. Med.  Heal., vol. 2, no. 4, pp. 1009–9, 2019,  doi: doi.org/10.28932/jmh.v2i4.1057.
[8] K. Kusmiati, D. Priadi, and R. K. B.  R. Rahayu, “Antibacterial Activity  Test, Evaluation of Pharmacognosy  and Phytochemical Screening of  Some Extracts of Globe Amaranth  (Gomphrena globosa),†J. Pure Appl.  Chem. Res., vol. 6, no. 1, pp. 27–33,  2017, doi:  10.21776/ub.jpacr.2017.006.01.288.
[9] Manaf Z, P. F, and Darmawi,  “DAYA HAMBAT GETAH JARAK  CINA (Jatropha multifida L.)  TERHADAP Staphylococcus aureus  SECARA IN VITRO,†J. Med. Vet.,  vol. 7, no. 2, 2013, doi:  10.21157/j.med.vet..v7i2.2946.
[10] N. Hidayah, “Uji Aktivitas Ekstrak  Metanol Klika Anak Dara (Oblongus  burm f.) Terhadap Bakteri Penyebab  Jerawat,†Alauddin State Islamic  Universit, 2016.
[11] Y. Mulyani, D. Hidayat, and Y.  Fatimah, “Ekstrak Daun Katuk  (Sauropus androgynus (L) Merr)  Sebagai Antibakteri Terhadap  Propionibacterium acnes dan  Staphylococcus epidermidis,†Farm.  Lampung J., vol. 6, no. 2, pp. 46-54.,  2017.
[12] A. Satyarsa, H. Iqra, G. Pratama, P.  Sudarsa, L. Rusyati, and I. Swastika,  “i-LEPRA: POTENSI MIKROSFER  KOMBINASI FUKOIDAN DAN  MIP SPESIFIK ANTIGEN ML0405  SEBAGAI INOVASI VAKSIN  Mycobacterium leprae.,†Essent.  Essence Sci. Med. J., vol. 16, no. 1,  pp. 1–11, 2019.
[13] A. Ningtyas, “Perbedaan Konsentrasi  dan Uji Aktivitas Antibakteri Ekstrak  Etanolik Batang Pisang Kluthuk  (Musa Balbisiana Colla) terhadap  Staphylococcus aureus dan  Pseudomona aeruginosa,†Sebelas  Maret University, 2012.
[14] S. Marselia, M. Wibowo, and S.  Arreneuz, “Aktivitas Antibakteri  Ekstrak Daun Soma (Ploiarium  alternifolium Melch) Terhadap  Propionibacterium acnes,†Kim.  Khatulistiwa J., vol. 4, no. 4, pp. 72– 82, 2015.
[15] A. B. S. Satyarsa, “Potential of  Fucoidan From Brown Seaweeds  (Sargassum sp.) as Innovation  Therapy on Breast Cancer,†J. Med.  Heal., vol. 2, no. 3, pp. 909–19, 2019,  doi: 10.28932/jmh.v2i3.1235.
[16] A. Sulaiman, P. Astuti, and A. Shita,  “Uji Antibakteri Ekstrak Daun  Kersen (Muntingia calabura L.)  Terhadap Koloni Streptococcus  viridans,†Indones. J. Heal. Sci., vol.  1, no. 2, pp. 1–6, 2017.
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