THE SEVERITY OF COVID-19 IS ASSESSED FROM D-DIMER AND PLATELET LEVELS
DOI:
https://doi.org/10.24269/ijhs.v8i1.6736Abstract This research was conducted with purpose to analyse the association between D- dimer and thrombocyte levels for severity of COVID-19. Researchers used cross sectional method on 57 COVID-19 patients at the private hospital in Surakarta on the period June to September 2021. Data were taken using total sampling with patients who fulfil the criteria and using Spearman test to analyse the association between D-dimer and platelet levels on the severity COVID-19. The characteristics of the respondents studied were an average age was 57 years, male is more dominant than female with a total of 35 (61.4%), the average severity of respondents was seriously ill (with an average oxygen saturations of 89.39%), the dominant D-dimer level of the respondent is increased with an average of 1699.4 ng/ml, and the dominant platelet level of the respondent was normal with an average of 281.360/µl. Results of the analysis with spearman test obtained significance (p-value) 0.560 for the association between D-dimer and severity of COVID-19, while for the association between platelets and severity of COVID-19, significance (p-value) 0.475 were obtained. From the results can be drawn the conclusion there is no association between D-dimer or platelet levels on the severity of COVID-19 disease.Â
References
[1] Torjesen, I. 2021. Covid-19: Omicron may be more transmissible than other
[2] Kementerian Kesehatan Republik Indonesia. 2022. Media Informasi Resmi Terkini Penyakit Infeksi Emerging COVID 19 #Update 01 Oct
[3] Kontopodis, E., Pierros, V., Stravopodis, D. J., & Tsangaris, G. T. 2022. Prediction of SARS-CoV-2 Omicron Variant Immunogenicity, Immune Escape and Pathogenicity, through the Analysis of Spike Protein- Specific Core Unique Peptides. Vaccines, 10(3), 357.
[4] Yu, B., Li, X., Chen, J., Ouyang, M., Zhang, H., Zhao, X., & Tang, J. 2020. Evaluation of variation in D-dimer levels among COVID-19 and bacterial 49 pneumonia: a retrospective analysis. Journal of thrombosis and thrombolysis, 50(3), 548-557
[5] Deng, M., Qi, Y., Deng, L., Wang, H., Xu, Y., Li, Z., & Dai, Z. 2020. Obesity as a potential predictor of disease severity in young COVIDâ€19 patients: a retrospective study. Obesity, 28(10), 1815-1825.
[6] Yu, B., Li, X., Chen, J., Ouyang, M., Zhang, H., Zhao, X., & Tang, J. 2020. Evaluation of variation in D-dimer levels among COVID-19 and bacterial 49 pneumonia: a retrospective analysis. Journal of thrombosis and thrombolysis, 50(3), 548-557
[7] Shah, S., Shah, K., Patel, S. B., Patel, F. S., Osman, M., Velagapudi, P., & Garg, J. 2020. Elevated D-dimer levels are associated with increased risk of mortality in coronavirus disease 2019: a systematic review and meta-analysis. Cardiology in review.
[8] Rahman, M. A., Shanjana, Y., Tushar, M. I., Mahmud, T., Rahman, G. M. S., Milan, Z. H., & Reza, H. M. 2021. Hematological abnormalities and comorbidities are associated with COVID-19 severity among hospitalized patients: experience from Bangladesh. PLoS One, 16(7), e0255379. https://doi.org/10.1371/journal.pone. 0255379
[9] Baihaqi, F. A., & Rumaropen, H. 2022. Faktor-Faktor yang Berhubungan dengan Lama Rawat Inap Pasien COVID-19 di RSUD Serui Provinsi Papua: Studi Potong Lintang. Jurnal Penyakit Dalam Indonesia, 8(4), 187- 194.
[10] Ozenen, G. G., Bal, Z. S., Umit, Z., Bilen, N. M., Arslan, S. Y, Yurtseven, A., ... & Ozkinay, F. 2021. Demographic, clinical, and laboratory features of COVIDâ€19 in children: The role of mean platelet volume in predicting hospitalization and severity. Journal of Medical Virology, 93(5), 3227-3237.
[11] Deng, M., Qi, Y., Deng, L., Wang, H., Xu, Y., Li, Z., & Dai, Z. 2020. Obesity as a potential predictor of disease severity in young COVIDâ€19 patients: a retrospective study. Obesity, 28(10),
1815-1825.
[12] Akbar, N. A., Rahardjo, A. M., Parti, D. D., & Sakinah, E. N. 2022. Analysis of the Relationship between Laboratory Biomarkers and the Severity of COVID-19 at Kaliwates General Hospital Jember. Journal of Agromedicine and Medical Sciences, 8(1).
[13] Lodigiani, C., Iapichino, G., Carenzo, L., Cecconi, M., Ferrazzi, P., Sebastian, T., & Force, T. 2020. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thrombosis research, 191, 9-14.
[14] Ozen, M., Yilmaz, A., Cakmak, V., Beyoglu, R., Oskay, A., Seyit, M., & Senol, H. 2021. D-Dimer as a potential biomarker for disease severity in COVID-19. The American journal of emergency medicine, 40, 55-59.
[15] Ozenen, G. G., Bal, Z. S., Umit, Z., Bilen, N. M., Arslan, S. Y, Yurtseven, A., ... & Ozkinay, F. 2021. Demographic, clinical, and laboratory features of COVIDâ€19 in children: The role of mean platelet volume in predicting hospitalization and severity. Journal of Medical Virology, 93(5), 3227-3237.
[16] Patil, S., Bhadake, M., Acharya, A., & Narwade, G. 2022. Role of D-Dimer in Covid-19 pneumonia: sensitive marker of inflammation, predictor of mechanical ventilation, thromboembolic events and early
[17] Kenya, C., Bunawan, N. C., Nugroho, H. M., Harlivasari, A. D., Sigarlaki, E. D., & Rinaldi, I. 2022. COVID-19 with extreme thrombocytosis: a case report and its possible mechanisms. Caspian Journal of Internal Medicine, 13(Suppl 3), 289.
[18] Yu, B., Li, X., Chen, J., Ouyang, M., Zhang, H., Zhao, X., & Tang, J. 2020. Evaluation of variation in D-dimer levels among COVID-19 and bacterial 49 pneumonia: a retrospective analysis. Journal of thrombosis and thrombolysis, 50(3), 548-557
[19] Yu, H. H., Qin, C., Chen, M., Wang, W., & Tian, D. S. 2020. D-dimer level is associated with the severity of COVID-19. Thrombosis research, 195, 219- 225
[20] Setiadi, W., Rozi, I. E., Safari, D., Daningrat, W. O. D., Johar, E., Yohan, B., & Wascove. 2022. Prevalence and epidemiological characteristics of COVID-19 after one year of pandemic in Jakarta and neighbouring areas, Indonesia: A single center study. PloS one, 17(5), e0268241
[2] Kementerian Kesehatan Republik Indonesia. 2022. Media Informasi Resmi Terkini Penyakit Infeksi Emerging COVID 19 #Update 01 Oct
[3] Kontopodis, E., Pierros, V., Stravopodis, D. J., & Tsangaris, G. T. 2022. Prediction of SARS-CoV-2 Omicron Variant Immunogenicity, Immune Escape and Pathogenicity, through the Analysis of Spike Protein- Specific Core Unique Peptides. Vaccines, 10(3), 357.
[4] Yu, B., Li, X., Chen, J., Ouyang, M., Zhang, H., Zhao, X., & Tang, J. 2020. Evaluation of variation in D-dimer levels among COVID-19 and bacterial 49 pneumonia: a retrospective analysis. Journal of thrombosis and thrombolysis, 50(3), 548-557
[5] Deng, M., Qi, Y., Deng, L., Wang, H., Xu, Y., Li, Z., & Dai, Z. 2020. Obesity as a potential predictor of disease severity in young COVIDâ€19 patients: a retrospective study. Obesity, 28(10), 1815-1825.
[6] Yu, B., Li, X., Chen, J., Ouyang, M., Zhang, H., Zhao, X., & Tang, J. 2020. Evaluation of variation in D-dimer levels among COVID-19 and bacterial 49 pneumonia: a retrospective analysis. Journal of thrombosis and thrombolysis, 50(3), 548-557
[7] Shah, S., Shah, K., Patel, S. B., Patel, F. S., Osman, M., Velagapudi, P., & Garg, J. 2020. Elevated D-dimer levels are associated with increased risk of mortality in coronavirus disease 2019: a systematic review and meta-analysis. Cardiology in review.
[8] Rahman, M. A., Shanjana, Y., Tushar, M. I., Mahmud, T., Rahman, G. M. S., Milan, Z. H., & Reza, H. M. 2021. Hematological abnormalities and comorbidities are associated with COVID-19 severity among hospitalized patients: experience from Bangladesh. PLoS One, 16(7), e0255379. https://doi.org/10.1371/journal.pone. 0255379
[9] Baihaqi, F. A., & Rumaropen, H. 2022. Faktor-Faktor yang Berhubungan dengan Lama Rawat Inap Pasien COVID-19 di RSUD Serui Provinsi Papua: Studi Potong Lintang. Jurnal Penyakit Dalam Indonesia, 8(4), 187- 194.
[10] Ozenen, G. G., Bal, Z. S., Umit, Z., Bilen, N. M., Arslan, S. Y, Yurtseven, A., ... & Ozkinay, F. 2021. Demographic, clinical, and laboratory features of COVIDâ€19 in children: The role of mean platelet volume in predicting hospitalization and severity. Journal of Medical Virology, 93(5), 3227-3237.
[11] Deng, M., Qi, Y., Deng, L., Wang, H., Xu, Y., Li, Z., & Dai, Z. 2020. Obesity as a potential predictor of disease severity in young COVIDâ€19 patients: a retrospective study. Obesity, 28(10),
1815-1825.
[12] Akbar, N. A., Rahardjo, A. M., Parti, D. D., & Sakinah, E. N. 2022. Analysis of the Relationship between Laboratory Biomarkers and the Severity of COVID-19 at Kaliwates General Hospital Jember. Journal of Agromedicine and Medical Sciences, 8(1).
[13] Lodigiani, C., Iapichino, G., Carenzo, L., Cecconi, M., Ferrazzi, P., Sebastian, T., & Force, T. 2020. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thrombosis research, 191, 9-14.
[14] Ozen, M., Yilmaz, A., Cakmak, V., Beyoglu, R., Oskay, A., Seyit, M., & Senol, H. 2021. D-Dimer as a potential biomarker for disease severity in COVID-19. The American journal of emergency medicine, 40, 55-59.
[15] Ozenen, G. G., Bal, Z. S., Umit, Z., Bilen, N. M., Arslan, S. Y, Yurtseven, A., ... & Ozkinay, F. 2021. Demographic, clinical, and laboratory features of COVIDâ€19 in children: The role of mean platelet volume in predicting hospitalization and severity. Journal of Medical Virology, 93(5), 3227-3237.
[16] Patil, S., Bhadake, M., Acharya, A., & Narwade, G. 2022. Role of D-Dimer in Covid-19 pneumonia: sensitive marker of inflammation, predictor of mechanical ventilation, thromboembolic events and early
[17] Kenya, C., Bunawan, N. C., Nugroho, H. M., Harlivasari, A. D., Sigarlaki, E. D., & Rinaldi, I. 2022. COVID-19 with extreme thrombocytosis: a case report and its possible mechanisms. Caspian Journal of Internal Medicine, 13(Suppl 3), 289.
[18] Yu, B., Li, X., Chen, J., Ouyang, M., Zhang, H., Zhao, X., & Tang, J. 2020. Evaluation of variation in D-dimer levels among COVID-19 and bacterial 49 pneumonia: a retrospective analysis. Journal of thrombosis and thrombolysis, 50(3), 548-557
[19] Yu, H. H., Qin, C., Chen, M., Wang, W., & Tian, D. S. 2020. D-dimer level is associated with the severity of COVID-19. Thrombosis research, 195, 219- 225
[20] Setiadi, W., Rozi, I. E., Safari, D., Daningrat, W. O. D., Johar, E., Yohan, B., & Wascove. 2022. Prevalence and epidemiological characteristics of COVID-19 after one year of pandemic in Jakarta and neighbouring areas, Indonesia: A single center study. PloS one, 17(5), e0268241
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