EFFECTIVENESS OF ANTIBACTERIAL EXTRACT OF KENOP (GOMPHRENA GLOBOSA) FLOWER EXTRACT AGAINST GROWTH OF PROPIONIBACTERIUM ACNES BACTERIA

Elvina Veronica; Sang Ayu Arta Suyantari; Widia Danis Swari; Ni Made Ari Purwaningrum; agung bagus sista satyarsa; i made jawi; Prima S. Sudarsa

doi:10.24269/ijhs.v4i2.2620

EFFECTIVENESS OF ANTIBACTERIAL EXTRACT OF KENOP (GOMPHRENA GLOBOSA) FLOWER EXTRACT AGAINST GROWTH OF PROPIONIBACTERIUM ACNES BACTERIA

Elvina Veronica* - Udayana University, Indonesia

Sang Ayu Arta Suyantari - Udayana University, Indonesia

Widia Danis Swari - Udayana University, Indonesia

Ni Made Ari Purwaningrum - Udayana University, Indonesia

agung bagus sista satyarsa - Udayana University, Indonesia

i made jawi - Udayana University, Indonesia

Prima S. Sudarsa - Udayana University, Indonesia

DOI : 10.24269/ijhs.v4i2.2620

Acne is a chronic inflammation of the pilosebaceous tissue caused by the bacterium Propionibacterium acne (P.acnes) which often experiences antibiotic resistance. Research on the benefits of herbal plants in dealing with acne is still needed, one of which is the use of Knobs flowers (Gomphrena globosa) which is easily found and has potential as an antioxidant and antibacterial. This study aims to determine the effectiveness of the extract of the flower knob in inhibiting the growth of P.acnes bacteria. The design of this study was purely experimental with the Kirby-Bauer method using MHA (Mueller Hinton Agar) media. A positive control using clindamycin antibiotics and negative control using aquadest. The treatment group consisted of 25%, 50%, 75%, and 100% knob methanol extract with 3 replications. Data analysis using One Way ANOVA to find out the average difference between treatment groups. Based on the results of the study, it was found that the higher the concentration of the extract, the greater the inhibitory power as long as the extract had not reached saturated concentration (p <0.05). There is a decrease in the inhibition zone diameter at 100% concentration because it is influenced by the diffusion rate of a compound and other factors.

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Keywords

Acne; antibacterial; kenop flower (Gomphrena globosa); Propiobacterium acnes (P.acnes) bacterium; inhibitory zone

A. L. Dawson and R. P. Dellavalle, “Acne vulgaris,” BMJ, vol. 346, no. 7907, p. f2634, 2013, doi: 10.1136/bmj.f2634.
A. L. Zaenglein, “Acne vulgaris,” N. Engl. J. Med., vol. 379, no. 14, pp. 1343–1352, 2018, doi: 10.1056/NEJMcp1702493.
N. H. Cox, Fitzpatrick’s Dermatology in General Medicine., 7th ed., vol. 150, no. 4. New York: McGraw-Hill, 2012.
S. Arumugam and K. Watanabe, Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation. Niigata: Elsevier, 2017.
K. Bhate and H. C. Williams, “Epidemiology of acne vulgaris,” Br. J. Dermatol., vol. 168, no. 3, pp. 474–485, 2013, doi: 10.1111/bjd.12149.
M. E. Portillo, S. Corvec, O. Borens, and A. Trampuz, “Propionibacterium acnes: An underestimated pathogen in implant-associated infections,” Biomed Res. Int., vol. 2013, 2013, doi: 10.1155/2013/804391.
A. B. S. Satyarsa, “Potential Effects of Alkaloid vindolicine Substances in Tapak Dara Leafs (Catharanthus roseus (L.) G. Don) in Reducing Blood Glucose Levels,” J. Med. Heal., vol. 2, no. 4, pp. 1009–9, 2019, doi: doi.org/10.28932/jmh.v2i4.1057.
K. Kusmiati, D. Priadi, and R. K. B. R. Rahayu, “Antibacterial Activity Test, Evaluation of Pharmacognosy and Phytochemical Screening of Some Extracts of Globe Amaranth (Gomphrena globosa),” J. Pure Appl. Chem. Res., vol. 6, no. 1, pp. 27–33, 2017, doi: 10.21776/ub.jpacr.2017.006.01.288.
Manaf Z, P. F, and Darmawi, “DAYA HAMBAT GETAH JARAK CINA (Jatropha multifida L.) TERHADAP Staphylococcus aureus SECARA IN VITRO,” J. Med. Vet., vol. 7, no. 2, 2013, doi: 10.21157/j.med.vet..v7i2.2946.
N. Hidayah, “Uji Aktivitas Ekstrak Metanol Klika Anak Dara (Oblongus burm f.) Terhadap Bakteri Penyebab Jerawat,” Alauddin State Islamic Universit, 2016.
Y. Mulyani, D. Hidayat, and Y. Fatimah, “Ekstrak Daun Katuk (Sauropus androgynus (L) Merr) Sebagai Antibakteri Terhadap Propionibacterium acnes dan Staphylococcus epidermidis,” Farm. Lampung J., vol. 6, no. 2, pp. 46-54., 2017.
A. Satyarsa, H. Iqra, G. Pratama, P. Sudarsa, L. Rusyati, and I. Swastika, “i-LEPRA: POTENSI MIKROSFER KOMBINASI FUKOIDAN DAN MIP SPESIFIK ANTIGEN ML0405 SEBAGAI INOVASI VAKSIN Mycobacterium leprae.,” Essent. Essence Sci. Med. J., vol. 16, no. 1, pp. 1–11, 2019.
A. Ningtyas, “Perbedaan Konsentrasi dan Uji Aktivitas Antibakteri Ekstrak Etanolik Batang Pisang Kluthuk (Musa Balbisiana Colla) terhadap Staphylococcus aureus dan Pseudomona aeruginosa,” Sebelas Maret University, 2012.
S. Marselia, M. Wibowo, and S. Arreneuz, “Aktivitas Antibakteri Ekstrak Daun Soma (Ploiarium alternifolium Melch) Terhadap Propionibacterium acnes,” Kim. Khatulistiwa J., vol. 4, no. 4, pp. 72– 82, 2015.
A. B. S. Satyarsa, “Potential of Fucoidan From Brown Seaweeds (Sargassum sp.) as Innovation Therapy on Breast Cancer,” J. Med. Heal., vol. 2, no. 3, pp. 909–19, 2019, doi: 10.28932/jmh.v2i3.1235.
A. Sulaiman, P. Astuti, and A. Shita, “Uji Antibakteri Ekstrak Daun Kersen (Muntingia calabura L.) Terhadap Koloni Streptococcus viridans,” Indones. J. Heal. Sci., vol. 1, no. 2, pp. 1–6, 2017.